User blog comment:Hyperborean/"The House of Hades" – official expectations blog/@comment-12369597-20130716052835/@comment-3146930-20130716102500

No it doesn't. Annabeth or any other character in the series could be the one mentioned in the prophecy. As far as what Annabeth means, from everything I have seen, it means "The grace of the house of God" or "He (God) has favored me." It pretty much means that the gods favor Annabeth or that Annabeth has pledged herself to the gods. Makes sense as Athena watches over her and Annabeth is always helping the gods in some way.