- This article is about the real Talos. For the prototype fought during The Titan's Curse, see Talos (prototype).
Talos protected Europa in Crete, circling the island's shores three times daily while guarding it and throwing stones at any unknown approaching ships to protect the island.
When the original Jason and the Argonauts approached the island of Crete after obtaining the Golden Fleece to load up on supplies, Talos, as the island's guardian, kept the Argo at bay by hurling great sized boulders at it. Medea, the sorceress, either drove him mad with drugs, or fooled him into believing that she could make him immortal by removing a nail and killed him with the same nail.
Percy Jackson, Thalia Grace, Grover Underwood, Zoë Nightshade, and Bianca di Angelo fought a malfunctioning prototype of Talos, which was at least 200 feet tall. Bianca stole an item from Hephaestus Junkyard, triggering its attack. Since Hephaestus is very protective of his belongings (according to Aphrodite), even discarded ones, the automaton begins functioning when someone steals something from the junkyard. In this case, a small figure of Hades was stolen by Bianca for Nico di Angelo, her brother, as it was the only figure he did not have in his Mythomagic collection. While fighting, the heroes find a hole at the bottom of the automaton's foot. Percy distracted the robot and Bianca enters the hole to try and make the machine malfunction, so that they could defeat him. He fell on some power lines and got electrocuted, killing Bianca in the process.
- In the 1963 film, Jason and the Argonauts, Talos guarded the "Isle of Bronze", he was awoken when some Argonauts stole treasure. He was encountered before the Argo reached Colchis, as a result, Hera was the one who told Jason to remove his nail instead of Medea. Talos' defeat also caused Hylas' death resulting in Hercules departure instead of what happened on the coast of Anatolia.